3-Chlorothiophene-2-carbonyl chloride → HCID 69088651, compound

HRID 1823873Notes

Reaction equation

HRID 1823873 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11](=[N:13][OH:14])[NH2:12])=[C:6]2[N:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[CH:3]=1.[Cl:19][C:20]1[CH:24]=[CH:23][S:22][C:21]=1[C:25](Cl)=O>>[Cl:19][C:20]1[CH:24]=[CH:23][S:22][C:21]=1[C:25]1[O:14][N:13]=[C:11]([C:10]2[CH:9]=[N:8][N:7]3[C:2]([CH3:1])=[CH:3][C:4]([C:15]([F:18])([F:16])[F:17])=[N:5][C:6]=23)[N:12]=1

Participants

3

Reactant 2

HCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 2819671HCID 2819671, compound

Product 1

HCID 69088651HCID 69088651, compound

Procedure

The title compound was prepared from 7-methyl-5-trifluoromethyl-pyrazolo[1,5-α]pyrimidine-3-amidoxime (13.8 mg, 0.0532 mmol) and 3-chloro-thiophene-2-carbonyl chloride (9.8 mg, 0.0541 mmol) similar to Example 16, and yielded 9.8 mg (48%) of an off-white solid. 1H NMR (CDCl3): 8.89 (s, 1H), 7.62 (d, J=5.22 Hz, 1H), 7.20 (d, J=0.83 Hz, 1H), 7.14 (d, J=5.22 Hz, 1H), 2.98 (s, 3H).

Sources & evidence

ORD record
ord-ff3a06812eae4388b89d80e58e8fba08
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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