Lithium Hydroxide → HCID 22147950, compound

HRID 1823904Notes

Reaction equation

HRID 1823904 reaction equation
C[O:2][C:3](=[O:24])[CH:4]([NH:13][CH2:14][CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=1.[Li+].[OH-]>O>[C:20]([O:19][C:17]([NH:16][CH2:15][CH2:14][NH:13][CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=1)[C:3]([OH:24])=[O:2])=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 23570952HCID 23570952, compound

Product 1

HCID 22147950HCID 22147950, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of (2-tert-butoxycarbonylamino-ethylamino)-(3-methoxy-phenyl)-acetic acid methyl ester (10.4 mmol) in TiAF:H2O (3:1, 40 mL) was added LiOH (10.9 mmol) and the reaction mixture was stirred for 3 hours at room temperature. The reaction mixture was concentrated in vacuo then diluted with H20 and neutralised with 2M HCl solution and the resulting precipitate was collected by filtration to afford the title compound in 46% yield.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionthen diluted with H20
  3. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-bfcf28a4158a48ad8cf8d5c6cf8bf468
Source dataset
uspto-grants-2006_05
Patent number
US07041687B2

Reaction notes

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