Diisopropylamine → HCID 23570957, compound

Temperature

-78 °C

Butyllithium (4.1 mL of 2.5M solution in hexanes, 10.3 mmol) was added to a solution of diisopropylamine (1.4 mL, 10.3 mmol) in THF (15 mL) under nitrogen at 0° C. After 15 minutes the reaction mixture was cooled to −78° C. and a solution of 3-chloro-2,6-difluorophenylacetic acid methyl ester (2.15 g, 9.8 mmol) in THF (15 mL) was added. After 30 minutes, iodoacetonitrile (3.5 mL, 49 mmol) was added rapidly to the reaction mixture. The reaction mixture was allowed to warm to 0° C. and ammonium chloride solution added (10 mL, saturated aqueous). The reaction mixture was concentrated and the residue partitioned between EtOAc and brine. The aqueous phase was extracted with EtOAc and the combined organics were dried over magnesium sulfate then concentrated to afford a black oil. The crude product was purified by column chromatography (silica, 25% EtOAc-petrol to EtOAc) to afford the title compound as a pale yellow oil (1.51 g, 59%); 1H NMR (400 MHz, DMSO) δ 3.06 (1H, dd), 3.19 (1H, dd), 3.67 (3H, s), 4.64 (1H, dd), 7.29 (1H, t), 7.70 (1H, m).

1. temperatureto warm to 0° C.
2. concentrationThe reaction mixture was concentrated
3. customthe residue partitioned between EtOAc and brine
4. extractionThe aqueous phase was extracted with EtOAc
5. dry with materialthe combined organics were dried over magnesium sulfate
6. concentrationthen concentrated
7. customto afford a black oil
8. customThe crude product was purified by column chromatography (silica, 25% EtOAc-petrol to EtOAc)

ORD record

ord-9a33b836e19f4121961b2e9afafd8fb2

Source dataset

uspto-grants-2006_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07041687B2