反应详情

A mixture of cis-benzyl-3-(5-fluoro-1H-indol-3-yl)-cyclopentylamine (0.45 g, 1.46 mmol), 0.2 g 10% Pd/C and ammonium formate (1.0 g, 15.9 mmol) in methanol (30 mL) were refluxed under nitrogen for 4 hours. The reaction mixture was cooled, filtered through celite, and concentrated. The residue was diluted with 1 N aqueous NaOH (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), then were dried over anhydrous sodium sulfate, filtered and concentrated to give 0.28 g (quant.) of the title compound as a thick oil: MS (ESI) m/z 219 [M+H]+.

1. temperaturewere refluxed under nitrogen for 4 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered through celite
4. concentrationconcentrated
5. additionThe residue was diluted with 1 N aqueous NaOH (50 mL)
6. extractionextracted with ethyl acetate (3×50 mL)
7. washThe combined organic layers were washed with water (50 mL) and brine (50 mL)
8. dry with materialwere dried over anhydrous sodium sulfate
9. filtrationfiltered
10. concentrationconcentrated