反应详情

FMOC-Leu*-Cl was prepared by dissolving FMOC—N-isobutylglycine (150 mg, 0.42 mmol) in CH2Cl2 (2.8 mL), and adding thionyl chloride (309 μL, 4.2 mmol) and 3 μL DMF (0.04 mmol). The reaction mixture was stirred for 5 hours and concentrated in vacuo., repeatedly dissolving in CH2Cl2 (3××) to provide FMOC-Leu*-Cl as a colorless oil (146 mg. 92%): IR (cm−1)-1804, 1720, 1715. FMOC-Phe*-Cl was similarly prepared.

1. customFMOC-Leu*-Cl was prepared
2. concentrationconcentrated in vacuo
3. dissolution, repeatedly dissolving in CH2Cl2 (3××)