Pyridine → HCID 67255324, compound

HRID 1824359Notes

Reaction equation

HRID 1824359 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1.N1C=CC=CC=1.[Cl:26][C:27]1[N:28]=[C:29]2[N:33]([C:34]=1[S:35](Cl)(=[O:37])=[O:36])[CH:32]=[CH:31][S:30]2>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:35]([C:34]2[N:33]3[C:29]([S:30][CH:31]=[CH:32]3)=[N:28][C:27]=2[Cl:26])(=[O:36])=[O:37])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 27997176-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chlorideHCID 98619383-Chloro-4-(napthalen-2-ylsulfanyl)-phenylamine

Product 1

HCID 67255324HCID 67255324, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared using the method of example 94, starting with 3-chloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (92) (150 mg, 0.53 mmol), pyridine (Aldrich, 0.21 mL, 2.63 mmol) and 6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl chloride (Maybridge, 149 mg, 0.58 mmol) in THF. 172 mg (65%) of 98 was obtained as a pale yellow solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-c14af2d7c0dd4b4980c1b0f60a9f7917
Source dataset
uspto-grants-2006_05
Patent number
US07041691B1

Reaction notes

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