Trifluoroacetic acid → HCID 58632019, compound

HRID 1824426Notes

Reaction equation

HRID 1824426 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[N:9]2[C:10](=[O:24])[CH:11]([NH:16]C(OC(C)(C)C)=O)[CH2:12][CH2:13][CH2:14][CH2:15][CH:8]2[CH2:7][CH2:6]1)=[O:4].FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]([C@H:5]1[N:9]2[C:10](=[O:24])[C@@H:11]([NH2:16])[CH2:12][CH2:13][CH2:14][CH2:15][C@H:8]2[CH2:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23571425HCID 23571425, compound

Product 1

HCID 58632019HCID 58632019, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-tert-butoxycarbonylamino-5-oxo-decahydro-pyrrolo[1,2-a]azocine-3-carboxylic acid methyl ester, 17, (272 mg, 0.8 mmol) is dissolved in dichloromethane (5 mL) and treated trifluroacetic acid (5 mL). The solution is stirred for two hours then the solvent removed in vacuo to afford the desired product which is used without further purification.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-a4314d3aca1f40b1a6cdc8a129cb3812
Source dataset
uspto-grants-2006_05
Patent number
US07041696B2

Reaction notes

Loading…