HCID 178505790, compound → HCID 178511654, compound

HRID 1824458Notes

Reaction equation

HRID 1824458 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH2:8])[CH2:4][CH2:3]1.Cl[C:10]1[NH:11][C:12]([NH:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)=[C:13]2[C:17]([N:18]=1)=[N:16][CH:15]=[N:14]2>>[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:10]2[NH:11][C:12]([NH:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[C:13]3[C:17]([N:18]=2)=[N:16][CH:15]=[N:14]3)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 178505790HCID 178505790, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 178511654HCID 178511654, compound

Conditions

Temperature
140 °C

Procedure

570 mg of trans-1,4-diaminocyclohexane are heated to its melting point 70° C., 290 mg of the product obtained in stage 1 above are added and the medium is then heated at approximately 140° C. for about 4 hours and then left overnight at room temperature. After purification by chromatography on silica with, as eluent, a mixture of CH2Cl2:MeOH:NH4OH (75:22:3) 93 mg of the expected product are obtained in the form of a beige crumbly foam.

Workup

  1. additionabove are added
  2. customAfter purification by chromatography on silica with, as eluent
  3. additiona mixture of CH2Cl2:MeOH:NH4OH (75:22:3) 93 mg of the expected product
  4. customare obtained in the form of a beige crumbly foam

Sources & evidence

ORD record
ord-6161ce87d47a422ba0ebfecb3612d3e3
Source dataset
uspto-grants-2006_05
Patent number
US07041824B2

Reaction notes

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