HCID 178418361, compound → HCID 178468999, compound

HRID 1824478Notes

Reaction equation

HRID 1824478 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]2[N:19]=[C:18]3[C:14]([N:15]=[CH:16][NH:17]3)=[C:13]([NH:20][C:21]3[CH:31]=[CH:30][C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:23][CH:22]=3)[N:12]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>C(OCC)(=O)C.CO.[Pt]=O>[NH2:1][C:4]1[CH:5]=[C:6]([NH:10][C:11]2[N:19]=[C:18]3[C:14]([N:15]=[CH:16][NH:17]3)=[C:13]([NH:20][C:21]3[CH:31]=[CH:30][C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:23][CH:22]=3)[N:12]=2)[CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178469000HCID 178469000, compound

Product 1

HCID 178468999HCID 178468999, compoundYield 39.3%

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

214 mg of the product of Example 24 are treated with 95 mg of platinum oxide (PtO2) in a mixture of 2.6 ml of ethyl acetate and 2.6 ml of methanol in the presence of hydrogen, H2. 78 mg of the expected product are thus obtained.

Sources & evidence

ORD record
ord-d5f434619dda4af38ea5e5b2db066159
Source dataset
uspto-grants-2006_05
Patent number
US07041824B2

Reaction notes

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