反应详情

Acryloyl chloride (0.33 mL, 4.10 mmole) was added to a solution of 3-(methylaminomethyl)-1H-indole (0.60 g, 3.70 mmole) and Et3N (1.03 mL, 7.40 mmole) in CH2Cl2 (30 mL) at 0° C. The reaction was held at 0° C. for ten minutes, then was stirred overnight at RT. The solution was concentrated in vacuo and the residue was diluted with water. The solution was extracted with ethyl acetate, and the combined organic extracts were washed with brine and dried over Na2SO4. The title compound (0.64 g, 80%) was obtained as a light yellow solid: MS (ES) m/e 215 (M+H)+.

1. waitThe reaction was held at 0° C. for ten minutes
2. concentrationThe solution was concentrated in vacuo
3. additionthe residue was diluted with water
4. extractionThe solution was extracted with ethyl acetate
5. washthe combined organic extracts were washed with brine
6. dry with materialdried over Na2SO4