Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Cyclohexadiene → 4-{8-Methylimidazo[1,2-a]pyridin-2-yl}aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Cyclohexadiene | HCID 12343 | — |
| 반응물 | 2-(4'-Nitrophenyl)-8-methylimidazo[1,2-a]pyridine | HCID 22015666 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-{8-Methylimidazo[1,2-a]pyridin-2-yl}aniline | HCID 2771077 | 54.4% |
반응 단계
A mixture of the product of Step A (1.48 g) and 1,4-cyclohexadiene (6.2 mL) and palladium (10% wt on activated carbon) (1.4 g) in ethanol (100 mL) was stirred at reflux temperature for 2 hours and cooled to ambient temperature and stirred for 12 hours. The reaction mixture was filtered through a pad of celite and the celite pad rinsed with ethanol (100 mL) and methanol (100 mL). The filtrate was collected and evaporated to yield the title compound (710 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07041827B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-1026d69feb144eb29081c7ca8610294a |
| 출처 메모 | uspto-grants-2006_05 |