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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1824506생성일: 2026년 10월 25일

1,4-Cyclohexadiene → 4-{8-Methylimidazo[1,2-a]pyridin-2-yl}aniline

https://huagongshe.com/reaction/1824506

반응식

참여 물질

역할이름HCID투입량
반응물1,4-CyclohexadieneHCID 12343—
반응물2-(4'-Nitrophenyl)-8-methylimidazo[1,2-a]pyridineHCID 22015666—
촉매PalladiumHCID 23938—
용매EthanolHCID 702—
생성물4-{8-Methylimidazo[1,2-a]pyridin-2-yl}anilineHCID 277107754.4%

반응 단계

A mixture of the product of Step A (1.48 g) and 1,4-cyclohexadiene (6.2 mL) and palladium (10% wt on activated carbon) (1.4 g) in ethanol (100 mL) was stirred at reflux temperature for 2 hours and cooled to ambient temperature and stirred for 12 hours. The reaction mixture was filtered through a pad of celite and the celite pad rinsed with ethanol (100 mL) and methanol (100 mL). The filtrate was collected and evaporated to yield the title compound (710 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07041827B2
출처 데이터셋uspto-grants-2006_05
ORD IDord-1026d69feb144eb29081c7ca8610294a
출처 메모uspto-grants-2006_05