HCID 22142146, compound → HCID 67457713, compound

HRID 1824698Notes

Reaction equation

HRID 1824698 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][NH:14][C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:9][CH:8]=1.Cl[O-].[Na+]>ClCCl>[F:1][C:2]([F:24])([F:25])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]=[N:14][C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 22142146HCID 22142146, compoundHCID 23665760Sodium Hypochlorite

Product 1

HCID 67457713HCID 67457713, compoundYield 95.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product (0.42 g) of Step 4 of Example 1 was added dichloromethane (10 mL) and 5% aqueous sodium hypochlorite (20 mL). The two-phase mixture was stirred vigorously overnight at room temperature, the organic layer was separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a red oil (0.4 g).

Workup

  1. customthe organic layer was separated
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-f3b7ee55bae2494fa569df6815e8f2ce
Source dataset
uspto-grants-2006_05
Patent number
US07045512B2

Reaction notes

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