270917-08-3 → 5-Chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole hydrochloride

HRID 1824712Notes

Reaction equation

HRID 1824712 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:18])[C:5]2[O:9][C:8]([N:10]3[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:7][C:6]=2[CH:17]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH3:18])[C:5]2[O:9][C:8]([N:10]3[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:7][C:6]=2[CH:17]=1

Participants

4

Reactant 2

HCID 9903419270917-08-3HCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 221423235-Chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole hydrochlorideYield 212.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-Chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole (12 g) was dissolved in ethyl acetate (200 mL), and the solution was added dropwise with 4 N hydrochloric acid/ethyl acetate (16.9 mL, Kokusan Kagaku Co., Ltd.) at room temperature with stirring. After the addition, the mixture was stirred for 30 minutes with ice cooling, and the produced colorless precipitates were collected by filtration. The precipitates were dried at 35 C.° under reduced pressure for 4 hours to obtain the title compound (14.5 g).

Workup

  1. additionAfter the addition
  2. stirringthe mixture was stirred for 30 minutes with ice cooling
  3. customthe produced colorless precipitates
  4. filtrationwere collected by filtration
  5. customThe precipitates were dried at 35 C.° under reduced pressure for 4 hours

Sources & evidence

ORD record
ord-d2adcb502f9e43f38f50f34d635ae291
Source dataset
uspto-grants-2006_05
Patent number
US07045516B1

Reaction notes

Loading…