Phosphorus oxychloride → 2-(4-Chlorophenyl)4-chloro-5,6,7,8-tetrahydroquinazoline

HRID 1824720Notes

Reaction equation

HRID 1824720 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:21])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517489HCID 178517489, compound

Product 1

HCID 111967212-(4-Chlorophenyl)4-chloro-5,6,7,8-tetrahydroquinazoline

Procedure

8.0 g of 2-(4-chlorophenyl)-4-hydroxy-5,6,7,8-tetrahydroquinazoline were heated to 100° C. in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was carefully poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature. Yield: 6.2 g; m.p.: 121° C.

Workup

  1. additionthe cooled solution was carefully poured onto ice water
  2. filtrationThe crystalline product was filtered off with suction
  3. washwashed well with water
  4. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-17378f48516545b6a8122404210c0143
Source dataset
uspto-grants-2006_05
Patent number
US07045526B2

Reaction notes

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