反应详情

A mixture of 0.65 gm (3.43 mMol) 3-bromo-4-fluorophenol, 0.60 mL (6.86 mMol) allyl bromide, and 0.71 gm (5.15 mMol) potassium carbonate in 6 mL acetone was stirred at reflux for 13 hours. The reaction mixture was concentrated under reduced pressure and the residue subjected to silica gel chromatography, eluting with hexane. Fractions containing product were combined and concentrated under reduced pressure to provide 61% of the desired compound.

1. temperatureat reflux for 13 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washeluting with hexane
4. additionFractions containing product
5. concentrationconcentrated under reduced pressure