HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 2-methylaziridine-1-carboxylate → (S)-N-tert-butoxycarbonyl 1-(5-fluorobenzofur-7-yl)-2-aminopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 2-methylaziridine-1-carboxylate | HCID 10942718 | — |
| Reactant | 7-Bromo-5-fluoro-1-benzofuran | HCID 22144816 | — |
| Product | (S)-N-tert-butoxycarbonyl 1-(5-fluorobenzofur-7-yl)-2-aminopropane | HCID 23573474 | 46% |
Reaction Steps
Beginning with 0.94 gm (4.4 mMol) 5-fluoro-7-bromobenzofuran and 0.63 mg (4 mMol) (S)-(+)-N-tert-butoxycarbonyl-2-methylaziridine, 0.534 gm (46%) of the desired compound were prepared essentially as described in Example 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045545B1 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-dfc591ea0ee4497aaa8d5f34f40ff73d |
| Source note | uspto-grants-2006_05 |