反应详情

A mixture of 0.11 gm (0.49 mMol) 2-methyl-2-(5-fluorobenzofur-7-yl)propionamide and 0.02 gm (0.49 mMol) lithium aluminium hydride in 2 mL tetrahydrofuran was stirred at room temperature for 1 hour. The reaction mixture was then treated sequentially with 38 μL water, 38 μL 15% sodium hydroxide, and 0.11 μL water. The reaction mixture was stirred vigorously for 1 hour and was then filtered. The filtrate was concentrated under reduced pressure to provide 0.018 gm (18%) 2-methyl-2-(5-fluorobenzofur-7-yl)-1-aminopropane. The hydrochloride salt was prepared to provide the title compound.

1. stirringThe reaction mixture was stirred vigorously for 1 hour
2. filtrationwas then filtered
3. concentrationThe filtrate was concentrated under reduced pressure