Hydrochloric Acid → HCID 12068606, compound

HRID 1824974Notes

Reaction equation

HRID 1824974 reaction equation
[OH-].[K+].[N+:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][CH2:16][CH3:17])[C:10]([C:18]([O:20]CC)=[O:19])=[CH:9]2)([O-:5])=[O:4].O.Cl>CS(C)=O>[N+:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][CH2:16][CH3:17])[C:10]([C:18]([OH:20])=[O:19])=[CH:9]2)([O-:5])=[O:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 12068604Ethyl 5-nitro-1-propyl-1H-indole-2-carboxylate

Product 1

HCID 12068606HCID 12068606, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

236 mg (3.68 mmol, 85% pure) of potassium hydroxide (powder) are initially charged in 10 ml of dimethyl sulphoxide, 961 mg (3.48 mmol) of the compound from Example I are added and the mixture is stirred at RT for half an hour. The reaction mixture is poured into about 100 ml of water and with cooling, 10% strength hydrochloric acid is added a little at a time to the solution until no more precipitate is formed. The precipitated solid is filtered off with suction and dried in a desiccator under reduced pressure overnight.

Workup

  1. temperaturewith cooling
  2. customis formed
  3. filtrationThe precipitated solid is filtered off with suction
  4. customdried in a desiccator under reduced pressure overnight

Sources & evidence

ORD record
ord-7cbdaef6fbe047e3a3fc583c9e072551
Source dataset
uspto-grants-2006_05
Patent number
US07045544B2

Reaction notes

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