Lithium Hydroxide → 1-(2-Fluorobenzyl)-5-{[(2-methyl-1,3-dioxolan-2-yl)acetyl]amino}-1H-indole-2-carboxylic acid

HRID 1824986Notes

Reaction equation

HRID 1824986 reaction equation
[F:1][C:2]1[CH:32]=[CH:31][CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[CH2:16][C:17]3([CH3:22])[O:21][CH2:20][CH2:19][O:18]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([O:26]CC)=[O:25].[OH-].[Li+]>>[F:1][C:2]1[CH:32]=[CH:31][CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[CH2:16][C:17]3([CH3:22])[O:21][CH2:20][CH2:19][O:18]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([OH:26])=[O:25]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 22144636Ethyl 1-(2-fluorobenzyl)-5-{[(2methyl-1,3-dioxolan-2-yl)acetyl]amino}-1H-indole-2-carboxylate

Product 1

HCID 221446721-(2-Fluorobenzyl)-5-{[(2-methyl-1,3-dioxolan-2-yl)acetyl]amino}-1H-indole-2-carboxylic acid

Procedure

Preparation analogously to Example XXII using 234 mg (0.63 mmol) of ethyl 1-(2-fluorobenzyl)-5-{[(2-methyl-1,3-dioxolan-2-yl)acetyl]amino}-1H-indole-2-carboxylate from Example XXXVIII and 0.53 ml (1.06 mmol) of lithium hydroxide solution.

Workup

  1. customPreparation analogously to Example XXII

Sources & evidence

ORD record
ord-b2df06330df947af9a684e237546ed3a
Source dataset
uspto-grants-2006_05
Patent number
US07045544B2

Reaction notes

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