Trifluoroacetic acid → HCID 23573394, compound

HRID 1824994Notes

Reaction equation

HRID 1824994 reaction equation
[NH:1]([C:8]([C:10]1[N:11]([CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])[C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([NH:19][C:20](=[O:26])[CH2:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:14][CH:13]=2)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH:1]([C:8]([C:10]1[N:11]([CH2:27][C:28]([OH:30])=[O:29])[C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([NH:19][C:20](=[O:26])[CH2:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[CH:14][CH:13]=2)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23573454HCID 23573454, compound

Product 1

HCID 23573394HCID 23573394, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

70 mg (0.15 mmol) of tert-butyl {2-(anilinecarbonyl)-5-[(3,3-dimethylbutanoyl)-amino]-1H-indol-1-yl}acetate from Example LIII, 0.50 ml of trifluoroacetic acid and 1 ml of dichloromethane are stirred together at RT for one hour. The solvent is removed under reduced pressure and the residue is dried in vacuo.

Workup

  1. customare stirred together at RT for one hour
  2. customThe solvent is removed under reduced pressure
  3. customthe residue is dried in vacuo

Sources & evidence

ORD record
ord-c2cff3194b124826bf3e2d572e16ce18
Source dataset
uspto-grants-2006_05
Patent number
US07045544B2

Reaction notes

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