Trifluoroacetic acid → (R)-2-Amino-2-(7-methoxy-naphthalen-2-yl)-ethanol

Participants

Reaction Steps

A solution of TFA (8 mL) and (R)-[2-hydroxy-1-(7-methoxy-naphthalen-2-yl)-ethyl]-carbamic acid tert-butyl ester (1.268 g) in methylene chloride (24 mL) was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound as a solid (860 mg).

Provenance & Evidence