反应详情

A solution of TFA (8 mL) and (R)-[2-hydroxy-1-(7-methoxy-naphthalen-2-yl)-ethyl]-carbamic acid tert-butyl ester (1.268 g) in methylene chloride (24 mL) was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound as a solid (860 mg).

1. concentrationAfter concentration
2. extractionextracted with methylene chloride
3. washThe organic layer was washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated