HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-{2-Amino-3,5-dicyano-6-[(2-pyridinylmethyl)sulphanyl]-4-pyridinyl}-phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 178474088 | HCID 178474088 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(4-{2-Amino-3,5-dicyano-6-[(2-pyridinylmethyl)sulphanyl]-4-pyridinyl}-phenyl)acetamide | HCID 9865716 | — |
Reaction Steps
9.28 g (30 mmol) of N-[4-(2-amino-3,5-dicyano-6-sulphanyl-4-pyridinyl)phenyl]-acetamide, 7.38 g (45 mmol) of 2-picolyl chloride hydrochloride and 10.08 g (120 mmol) of sodium hydrogen carbonate are stirred at room temperature in 100 ml of DMF. After 2 hours, 100 ml of water are added dropwise at from 40 to 50° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045631B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-bbb49fccfdde414ba7954bbae66f121b |
| Source note | uspto-grants-2006_05 |