Water → N-(4-{2-Amino-3,5-dicyano-6-[(2-pyridinylmethyl)sulphanyl]-4-pyridinyl}-phenyl)acetamide

HRID 1825301Notes

Reaction equation

HRID 1825301 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=2)[C:5]([C:20]#[N:21])=[C:4]([SH:22])[N:3]=1.Cl.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH2:30]Cl.C(=O)([O-])O.[Na+].O>CN(C=O)C>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=2)[C:5]([C:20]#[N:21])=[C:4]([S:22][CH2:30][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=2)[N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 23392Picolyl chloride hydrochlorideHCID 516892Sodium BicarbonateHCID 178474088HCID 178474088, compound

Product 1

HCID 9865716N-(4-{2-Amino-3,5-dicyano-6-[(2-pyridinylmethyl)sulphanyl]-4-pyridinyl}-phenyl)acetamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

9.28 g (30 mmol) of N-[4-(2-amino-3,5-dicyano-6-sulphanyl-4-pyridinyl)phenyl]-acetamide, 7.38 g (45 mmol) of 2-picolyl chloride hydrochloride and 10.08 g (120 mmol) of sodium hydrogen carbonate are stirred at room temperature in 100 ml of DMF. After 2 hours, 100 ml of water are added dropwise at from 40 to 50° C.

Sources & evidence

ORD record
ord-bbb49fccfdde414ba7954bbae66f121b
Source dataset
uspto-grants-2006_05
Patent number
US07045631B2

Reaction notes

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