HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1825311Generated: October 31, 2026
(Trifluoromethyl)benzene → 1-fluoroethylbenzene
https://huagongshe.com/reaction/1825311
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Trifluoromethyl)benzene | HCID 7368 | — |
| Reactant | 1-Phenylethanol | HCID 7409 | — |
| Reactant | HCID 178435160 | HCID 178435160 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-fluoroethylbenzene | HCID 9898821 | 81% |
Reaction Steps
Under a protective gas atmosphere 0.83 g (6.8 mmol) of 1-phenylethanol is added dropwise in the course of 5 min to a solution of 2.32 g (7.56 mmol) of i-Prop2N═CHF+HF2−.HNEt3+.HF2− in 10 ml of CH2Cl2 in a polyethylene container. The mixture is stirred for several hours at 20° C. and the conversion rate is analysed by 19F-NMR (reference: PhCF3). After 2.5 h, 81% of 1-fluoroethylbenzene is obtained, and after a stirring time of 24 h, 96% of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07045662B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-0cfce1f635a34c53b473ca79844a3855 |
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| Source note | uspto-grants-2006_05 |
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