(Trifluoromethyl)benzene → 1-fluoroethylbenzene
Reaction equation
[C:1]1([CH:7](O)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(F)(F)[F:17])C=CC=CC=1>C(Cl)Cl>[F:17][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
Under a protective gas atmosphere 0.83 g (6.8 mmol) of 1-phenylethanol is added dropwise in the course of 5 min to a solution of 2.32 g (7.56 mmol) of i-Prop2N═CHF+HF2−.HNEt3+.HF2− in 10 ml of CH2Cl2 in a polyethylene container. The mixture is stirred for several hours at 20° C. and the conversion rate is analysed by 19F-NMR (reference: PhCF3). After 2.5 h, 81% of 1-fluoroethylbenzene is obtained, and after a stirring time of 24 h, 96% of product is obtained.
Sources & evidence
- ORD record
- ord-0cfce1f635a34c53b473ca79844a3855
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07045662B2
Reaction notes
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