Potassium Carbonate → HCID 22145920, compound

HRID 1825413Notes

Reaction equation

HRID 1825413 reaction equation
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][C:12]1[N:17]=[N:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)(=O)C>O.CO>[CH3:19][O:18][C:15]1[N:16]=[N:17][C:12]([CH2:11][OH:10])=[CH:13][C:14]=1[O:20][CH3:21]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 22145882HCID 22145882, compound

Product 1

HCID 22145920HCID 22145920, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of potassium carbonate (0.2 g) in water 2 mL) is added to a solution of 6-acetoxymethyl-3,4-dimethoxypyridazine (0.27 g) in methanol (6 mL) and the mixture stirred at 60–70° C. for 2 hours. After evaporating to dryness the residue is partitioned between ethyl acetate (10 mL) and brine (10 mL). The ethyl acetate phase is evaporated to dryness and the residue purified by flash chromatography (ethyl acetate as eluent on silica) to give 3,4-dimethoxy-6-hydroxymethylpyridazine as a white solid, m.p. 151–3° C.

Workup

  1. customAfter evaporating to dryness the residue
  2. customis partitioned between ethyl acetate (10 mL) and brine (10 mL)
  3. customThe ethyl acetate phase is evaporated to dryness
  4. customthe residue purified by flash chromatography (ethyl acetate as eluent on silica)

Sources & evidence

ORD record
ord-f6b17fb6be7a482190aea48a12ad6da7
Source dataset
uspto-grants-2006_05
Patent number
US07045660B2

Reaction notes

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