6-Chloro-3-nitropyridin-2-ylamine → HCID 178430857, compound

HRID 1825580Notes

Reaction equation

HRID 1825580 reaction equation
[Br:1]C1C=C(C2C(C(Cl)=O)=CC=CC=2)[ClH]C=1.[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[C:19](Cl)[N:18]=1.[Cl:27][C:28]1[CH:33]=[C:32](Cl)[CH:31]=[CH:30][C:29]=1[C:35]1[C:40]([C:41]2[NH:42][CH:43]=[C:44]([CH3:46])[N:45]=2)=[CH:39][N:38]=[C:37]([NH:47][CH2:48][CH2:49][NH:50]C2N=CC(C#N)=CC=2)[N:36]=1>>[NH2:16][C:17]1[N:18]=[C:19]([NH:50][CH2:49][CH2:48][NH:47][C:37]2[N:36]=[C:35]([C:29]3[CH:30]=[CH:31][C:32]([Br:1])=[CH:33][C:28]=3[Cl:27])[C:40]([C:41]3[NH:42][CH:43]=[C:44]([CH3:46])[N:45]=3)=[CH:39][N:38]=2)[CH:20]=[CH:21][C:22]=1[N+:23]([O-:25])=[O:24]

Participants

3

Reactant 2

HCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 178430853HCID 178430853, compound

Product 1

HCID 178430857HCID 178430857, compound

Procedure

{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(4-bromo-2-chlorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amine was prepared from 4-bromo-2-chlorolbenzoyl chloride and 2-amino-6-chloro-3-nitropyridine using the general method for 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile.

Sources & evidence

ORD record
ord-e40c9449029d4d4190b5cbc866ba4947
Source dataset
uspto-grants-2006_05
Patent number
US07045519B2

Reaction notes

Loading…