反应详情

温度

90 °C

[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-9H-thioxanthen-2-yl]-carbamic acid tert-butyl ester (1.02 g, 2.32 mmol), 2-chloro-6-morpholin-4-yl-pyran-4-one (3) (0.60 g, 2.78 mmol) and K2CO3 (0.64 g, 4.64 mmol) were dissolved in dry 1,4-dioxane (ml). The mixture was degassed for 15 minutes and Pd(PPh3)4 (0.13 g, 0.12mol) was then added The dark brown mixture was heated to 90° C. under an atmosphere of N2 for 24 hour. The reaction mixture was concentrated in vacuo and water (50 ml) was added. The brown solid was filtered and washed with water (1.21 g, 88%). m/z (LC-MS, ESP), RT=4.6 minutes, (M++1)=493.

1. customThe mixture was degassed for 15 minutes
2. concentrationThe reaction mixture was concentrated in vacuo and water (50 ml)
3. additionwas added
4. filtrationThe brown solid was filtered
5. washwashed with water (1.21 g, 88%)