HCID 22139421, compound → HCID 22139427, compound

HRID 1825796Notes

Reaction equation

HRID 1825796 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][C:17]([OH:19])=O>CS(O)(=O)=O>[CH3:1][O:2][C:3]1[C:4]2[S:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:16][C:17](=[O:19])[C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 22139421HCID 22139421, compound

Product 1

HCID 22139427HCID 22139427, compound

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Conditions

Temperature
90 °C

Procedure

[2-(2-Methoxy-phenylsulfanyl)-phenyl]-acetic acid (5.40 g, 20 mmol) was dissolved in methanesulfonic acid (50 ml) and the mixture was heated for 2 hours at 90° C. under stirring and a nitrogen atmosphere. The reaction mixture was cooled to room temperature and poured onto ice with stirring. The black precipitate was filtered and dried over night in a vacuum oven (50° C.). The compound was used without any further purification (4.60 g, 91%).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. additionpoured onto ice
  3. stirringwith stirring
  4. filtrationThe black precipitate was filtered
  5. customdried over night in a vacuum oven (50° C.)
  6. customThe compound was used without any further purification (4.60 g, 91%)

Sources & evidence

ORD record
ord-0b23db445495489797204c8151666b08
Source dataset
uspto-grants-2006_05
Patent number
US07049313B2

Reaction notes

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