Morpholine → HCID 22139428, compound

HRID 1825806Notes

Reaction equation

HRID 1825806 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C([S:9][C:10](=S)[CH2:11][C:12](=[O:27])[C:13]1[C:26]2[S:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[S:18][C:17]=2[CH:16]=[CH:15][CH:14]=1)C>C(O)C>[N:1]1([C:10](=[S:9])[CH2:11][C:12]([C:13]2[C:26]3[S:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[S:18][C:17]=3[CH:16]=[CH:15][CH:14]=2)=[O:27])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 23574541HCID 23574541, compound

Product 1

HCID 22139428HCID 22139428, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Morpholine (0.96 ml, 11 mmol) was added to a solution of 3-oxo-3-thianthren-1-yl-dithiopropionic acid ethyl ester (3.99 g, 11 mmol) in ethanol (20 ml). The reaction was refluxed for 8 hours and was then cooled to room temperature. The precipitate formed was filtered and dried to give the desired product as a bright orange solid (3.50 g, 82%). m/z (LC-MS, ESP), RT=4.81 and 5.33 min same (M+1)=388

Workup

  1. temperatureThe reaction was refluxed for 8 hours
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-022a1c73f81d4182821dafebcacfc2d2
Source dataset
uspto-grants-2006_05
Patent number
US07049313B2

Reaction notes

Loading…