Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → HCID 11974826, compound

HRID 1826312Notes

Reaction equation

HRID 1826312 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:16][C:17]1[C:22]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][C:32]=3F)[N:27]=[CH:26][N:25]=2)=[C:21]2[O:35][CH2:36][O:37][C:20]2=[CH:19][CH:18]=1>Cl.C(OCC)C>[ClH:16].[ClH:16].[Cl:16][C:17]1[C:22]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][C:32]=3[O:15][CH2:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[N:27]=[CH:26][N:25]=2)=[C:21]2[O:35][CH2:36][O:37][C:20]2=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 11974447HCID 11974447, compound

Product 1

HCID 11974826HCID 11974826, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

Using an analogous procedure to that described in Example 37, N-(tert-butoxycarbonyl)piperidin-4-ylmethanol was reacted with 4-(6-chloro-2,3-methylenedioxyanilino)-5-fluoroquinazoline (0.1 g). The product so obtained was dissolved in a 2M solution of hydrogen chloride in diethyl ether (20 ml) and stirred at ambient temperature for 3 hours. The mixture was evaporated and the residue was triturated under diethyl ether. The solid so obtained was washed with diethyl ether and dried under vacuum. There was thus obtained the tilte compound (0.121 g); NMR Spectrum: (DMSOd6) 1.5–1.6 (m, 2H), 1.9–2.0 (m, 2H), 2.3–2.4 (m, 1H), 2.8–2.9 (m, 2H), 3.3 (d, 2H), 4.42 (d, 2H), 6.15 (s, 2H), 7.07 (d, 1H), 7.15 (d, 1H), 7.53 (m, 2H), 8.06 (m, 1H), 8.87 (s, 1H), 10.57 (br s, 1H); Mass Spectrum: M+H+ 413 and 415.

Workup

  1. customThe product so obtained
  2. customThe mixture was evaporated
  3. customthe residue was triturated under diethyl ether
  4. customThe solid so obtained
  5. washwas washed with diethyl ether
  6. customdried under vacuum

Sources & evidence

ORD record
ord-bad1d280dced4e93ac1c6c95d66ae53e
Source dataset
uspto-grants-2006_05
Patent number
US07049438B2

Reaction notes

Loading…