Nitronium tetrafluoroborate → HCID 22139632, compound

HRID 1826523Notes

Reaction equation

HRID 1826523 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=[C:3]1[CH:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1.F[B-](F)(F)F.[O:27]=[N+:28]=[O:29]>C(#N)C>[CH3:1][N:2]1[C:7](=[O:8])[C:6]([N+:28]([O-:29])=[O:27])=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=[C:3]1[CH:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 11073463Nitronium tetrafluoroborateHCID 221395743-Methyl-2-(1-methylpiperidin-4-yl)-6-(pyridin-4-yl)pyrimidin-4(3H)-one

Product 1

HCID 22139632HCID 22139632, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3-methyl-2-(1-methyl-piperidin-4-yl)-6-pyridin-4-yl-3H-pyrimidin-4-one (0.64 mmol) in acetonitrile (2.5 mL) at 0° C. was added 2.5 mL 0.5M solution of nitronium tetrafluoroborate. After 30 min, the reaction product was isolated and purified on silica. M+1=329.

Workup

  1. customthe reaction product was isolated
  2. custompurified on silica

Sources & evidence

ORD record
ord-513e238e47a841b2b43efcb8f9e71de2
Source dataset
uspto-grants-2006_05
Patent number
US07049318B2

Reaction notes

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