HCID 22139632, compound → HCID 22139631, compound

HRID 1826524Notes

Reaction equation

HRID 1826524 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([N+:9]([O-])=O)=[C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:4]=[C:3]1[CH:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1>CO.[Pd]>[NH2:9][C:6]1[C:7](=[O:8])[N:2]([CH3:1])[C:3]([CH:18]2[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]2)=[N:4][C:5]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 22139632HCID 22139632, compound

Product 1

HCID 22139631HCID 22139631, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirring solution of 3-methyl-2-(1-methyl-piperidin-4-yl)-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one (0.34 mmol) in methanol was added Pd/C (20 mg) and the reaction was stirred overnight under a hydrogen filled balloon. The reaction was filtered through celite then the product was purified on silica. M+1=299.

Workup

  1. filtrationThe reaction was filtered through celite
  2. customthe product was purified on silica

Sources & evidence

ORD record
ord-3c7bda66b97d4f1f84ead9b25d838d2f
Source dataset
uspto-grants-2006_05
Patent number
US07049318B2

Reaction notes

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