反应详情

A suspension of 1.0 g (5.2 mmol) of 2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (Example 5) in 10 mL of phosphorus oxychloride is heated under reflux for 1 hour. The resulting solution is cooled and concentrated to give a solid, which is triturated with cold water and filtered to give 1.05 g of crude product. Recrystallization from acetonitrile lives 0.76 g (69%) of the product, mp 201-203° C.

1. temperatureis heated
2. temperatureunder reflux for 1 hour
3. temperatureThe resulting solution is cooled
4. concentrationconcentrated
5. customto give a solid, which
6. customis triturated with cold water
7. filtrationfiltered