反应详情

温度

45 °C

A suspension of 6.74 g (47.8 mmol) of 4-fluoro-nitro-benzene and 10.91 g (95.5 mmol) of cis-2,6-dimethyl-piperazine is heated at 45° C. for 1 hour. The reaction mixture is cooled and shaken with dichloromethane and water. The organic layer is dried (magnesium sulfate) and concentrated to give 11.62 g (>100%) of the product as a solid.

1. temperatureThe reaction mixture is cooled
2. dry with materialThe organic layer is dried (magnesium sulfate)
3. concentrationconcentrated