HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826584Generated: November 4, 2026
Dichloromethane → cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine
https://huagongshe.com/reaction/1826584
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Solvent | Water | HCID 962 | — |
| Product | cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 7059963 | 103.3% |
Reaction Steps
A suspension of 6.74 g (47.8 mmol) of 4-fluoro-nitro-benzene and 10.91 g (95.5 mmol) of cis-2,6-dimethyl-piperazine is heated at 45° C. for 1 hour. The reaction mixture is cooled and shaken with dichloromethane and water. The organic layer is dried (magnesium sulfate) and concentrated to give 11.62 g (>100%) of the product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07053070B2 |
|---|
| Source dataset | uspto-grants-2006_05 |
|---|
| ORD ID | ord-c345d70e59794d199abe9ba7552457a8 |
|---|
| Source note | uspto-grants-2006_05 |
|---|
