tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate → HCID 23577081, compound

HRID 1826591Notes

Reaction equation

HRID 1826591 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:21]([O:23][C:24]([C:26]1[C:36]([NH2:37])=[N:35][C:29]2[N:30]=[C:31](Cl)[N:32]=[CH:33][C:28]=2[CH:27]=1)=[O:25])[CH3:22].CCCCCC.C(OCC)(=O)C>O1CCOCC1>[CH2:21]([O:23][C:24]([C:26]1[C:36]([NH2:37])=[N:35][C:29]2[N:30]=[C:31]([NH:20][C:17]3[CH:16]=[CH:15][C:14]([N:11]4[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:9][CH2:10]4)=[CH:19][CH:18]=3)[N:32]=[CH:33][C:28]=2[CH:27]=1)=[O:25])[CH3:22]

Participants

5

Reactant 3

HCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylateHCID 21226206Ethyl acetate hexaneHCID 86587672HCID 86587672, compound

Product 1

HCID 23577081HCID 23577081, compoundYield 16%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the product of Example 12 and the product of Example 129 in dioxane is heated under reflux for 1.5 hours. The reaction is poured into hexane/ethyl acetate (1:1), and the solid is collected. Flash chromatography using dichloromethane as eluant gave 0.08 g (16%) of the product as a solid.

Workup

  1. temperatureunder reflux for 1.5 hours
  2. customthe solid is collected

Sources & evidence

ORD record
ord-3ac00313c06e45ccb9d75740e48c6c17
Source dataset
uspto-grants-2006_05
Patent number
US07053070B2

Reaction notes

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