(R)-2-(4-Methoxybenzoylamino)-2-phenylethylazide → (R)-2-(4-methoxybenzoylamino)-2-phenylethylamine

HRID 1826600Notes

Reaction equation

HRID 1826600 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([C:7]([NH:9][C@H:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][N:12]=[N+]=[N-])=[O:8])=[CH:5][CH:4]=1>C1COCC1>[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([C:7]([NH:9][C@H:10]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:11][NH2:12])=[O:8])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 53998160(R)-2-(4-Methoxybenzoylamino)-2-phenylethylazide

Product 1

HCID 54421380(R)-2-(4-methoxybenzoylamino)-2-phenylethylamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using Deprotection Method A, (R)-2-(4-methoxybenzoylamino)-2-phenylethyl azide (46.3 g) in THF (400 mL) afforded, after recrystallization with ethyl acetate, 35.4 g (84%) of the title compound.

Workup

  1. customafforded
  2. customafter recrystallization with ethyl acetate, 35.4 g (84%) of the title compound

Sources & evidence

ORD record
ord-beb753aedf0a4158be152aa4f5a70f3e
Source dataset
uspto-grants-2006_05
Patent number
US07053078B2

Reaction notes

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