HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 3-[3-Methyl-4-(piperidine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyridin-4-yl-1,3-dihydroindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Pyridin-4-yl-1,3-dihydro-indol-2-one | HCID 12111581 | — |
| Reactant | 3-methyl-4-(piperidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde | HCID 22135468 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[3-Methyl-4-(piperidine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyridin-4-yl-1,3-dihydroindol-2-one | HCID 69188197 | 17% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 4-pyridin-4-yl-1,3-dihydroindol-2-one (60 mg, 0.3 mmol), 3-methyl-4-(piperidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (75 mg, 0.34 mmol) and piperidine (0.14 mL) in ethanol (2 mL) was stirred at 100° C. overnight. The reaction was column chromatographed (2–3% methanol in dichloromethane) to give 20 mg (17%) of the title compound as a yellow orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07053086B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-312f72c84fb3412ab7e801d53d86f5ea |
| Source note | uspto-grants-2006_05 |