2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid → 5-Methyl-2-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid

HRID 1826771Notes

Reaction equation

HRID 1826771 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)[CH2:3][CH2:2]1.[CH:17]([C:19]1[NH:20][C:21]([CH3:27])=[CH:22][C:23]=1[C:24]([OH:26])=[O:25])=O>>[CH3:27][C:21]1[NH:20][C:19]([CH:17]=[C:9]2[C:8]3[C:12](=[CH:13][CH:14]=[CH:15][C:7]=3[CH:4]3[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]3)[NH:11][C:10]2=[O:16])=[C:23]([C:24]([OH:26])=[O:25])[CH:22]=1

Participants

3

Reactant 2

HCID 219155882-formyl-5-methyl-1H-pyrrole-3-carboxylic acidHCID 221353964-(Piperidin-4-yl)indolin-2-one

Product 1

HCID 695841815-Methyl-2-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid

Procedure

4-Piperidin-4-yl-1,3-dihydroindol-2-one (45 mg, 0.2 mmol) was condensed with 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (34 mg, 0.23 mmol) to give the title compound.

Sources & evidence

ORD record
ord-542c6bf75bcf423c977bb6657e3de2f2
Source dataset
uspto-grants-2006_05
Patent number
US07053086B2

Reaction notes

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