1-Phenylpiperazine → [6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

HRID 1826824노트

반응식

HRID 1826824 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:3]=1.[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:19]1([N:25]2[CH2:30][CH2:29][N:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:18]=[C:17]5[C:12]([CH:13]=[CH:14][CH:15]=[N:16]5)=[CH:11][CH:10]=4)[CH:3]=3)[CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 70961-PhenylpiperazineHCID 11430Potassium CarbonateHCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

생성물 1

HCID 22135548[6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

This compound could be prepared from (6-chloro-pyrimidin-4-yl)-quinolin-7-yl-amine and 1-phenyl-piperazine in the presence of K2CO3 and DMF.

출처 및 근거

ORD 기록
ord-02a45cc5159f480ea313680cec3f9148
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053088B2

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