2-Aminoadamantane → HCID 8373251, compound

HRID 1826876Notes

Reaction equation

HRID 1826876 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][C:14]=1[C:23]([OH:25])=O.[CH:26]12[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH:27]1[NH2:36])[CH2:33]2>ClCCl>[CH:26]12[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH:27]1[NH:36][C:23]([C:14]1[CH:15]=[N:16][C:17]3[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:13]=1)=[O:25])[CH2:33]2

Participants

5

Reactant 3

HCID 253322-AminoadamantaneHCID 682631,1'-CarbonyldiimidazoleHCID 96695Quinoxaline-2-carboxylic acid

Product 1

HCID 8373251HCID 8373251, compoundYield 35.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 1,1′-carbonyldiimidazole (161 mg, 1.00 mmol), 2-quinoxalinecarboxylic acid (174 mg, 1.00 mmol), 2-adamantanamine (136 mg, 0.90 mmol), and dichloromethane (3.5 mL) yielding 98 mg (35%) of (144):

Sources & evidence

ORD record
ord-ee0d96098e774e7f90dfbc4b1bc10956
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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