3-Methylcyclohexylamine, mixed isomers → N-(3-Methylcyclohexyl)-2-quinoxalinecarboxamide

HRID 1826895Notes

Reaction equation

HRID 1826895 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[CH3:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([NH2:21])[CH2:16]1>N1C=CC=CC=1>[CH3:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([NH:21][C:11]([C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)=[O:12])[CH2:16]1

Participants

4

Reactant 2

HCID 1109313-Methylcyclohexylamine, mixed isomersHCID 2734681Quinoxaline-2-carbonyl chloride

Product 1

HCID 22136416N-(3-Methylcyclohexyl)-2-quinoxalinecarboxamideYield 78.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (193 mg, 1.0 mmol), 3-methylcyclohexylamine (119 mg, 0.90 mmol), and pyridine (5 mL) yielding 190 mg (78%) of (161):

Sources & evidence

ORD record
ord-0d22c7f232e6468d936e11142047278a
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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