Thionyl Chloride → HCID 178461307, compound

HRID 1826915Notes

Reaction equation

HRID 1826915 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([NH:12]C(C2C=NC3C(C=2Cl)=CC=CC=3C(F)(F)F)=O)[CH2:8][CH2:7]1>C(N(CC)CC)C>[ClH:3].[CH3:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178461358HCID 178461358, compound

Product 1

HCID 178461307HCID 178461307, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

4-Hydroxy-8-trifluoromethyl-3-carboxylic acid (514 mg, 2 mmol), thionyl chloride, trans-4-methylcyclohexylamine hydrochloride (225 mg, 1.5 mmol), and triethylamine (2 mL) afforded crude N-(trans-4-methylcyclohexyl)-4-chloro-8-trifluoromethylquinoline-3-carboxamide:

Sources & evidence

ORD record
ord-8d4d1060fe1f46938a3b8827f4aa2546
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

Loading…