Aniline → HCID 9927213, compound

HRID 1826932Notes

Reaction equation

HRID 1826932 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:16][CH:15]=[N:14][CH:13]=2)=[C:8]([O:17][CH3:18])[CH:7]=1)=[O:4].[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CN(C=O)C>[CH3:18][O:17][C:8]1[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:11]=[CH:10][C:9]=1[C:12]1[O:16][CH:15]=[N:14][CH:13]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 22058519HCID 22058519, compound

Product 1

HCID 9927213HCID 9927213, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2A (30.0 mg, 0.11 mmol) and aniline (30 μL, 0.33 mmol) in DMF (0.1 mL) was heated at 100° C. for 2.5 h. After the reaction had cooled, the solvent was removed under reduced pressure, and the residue was subjected to preparative HPLC to give 2 as a yellow solid. LC/MS: ret. timeA=3.576 min., MS (M+H)+=324.

Workup

  1. temperatureAfter the reaction had cooled
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-6e4b24b4bce0425c9ff6f5bab88d65cb
Source dataset
uspto-grants-2006_05
Patent number
US07053111B2

Reaction notes

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