Hydrochloric Acid → HCID 69661986, compound

HRID 1826991Notes

Reaction equation

HRID 1826991 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.[O:13]1CCOCC1>>[ClH:1].[NH2:7][CH2:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:10][C:9]=1[C:8]([OH:11])=[O:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 124964756-Chloro-2,3-dihydro-1H-isoindol-1-one

Product 1

HCID 69661986HCID 69661986, compoundYield 4%

Conditions

Temperature
110 °C

Procedure

A mixture of 6-chloro-2,3-dihydro-isoindol-1-one (0.115 g, 0.68 mmol) and 6M hydrochloric acid (8 ml) in dioxan (1 ml) was heated to 110° C. for 18 hours. After cooling to room temperature the solid was filtered off and dried in vacuo to give the title compound (0.0055 g, 4%) as a beige solid.

Workup

  1. temperatureAfter cooling to room temperature the solid
  2. filtrationwas filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-b3ab6d55020f42c5a286a5250f02551b
Source dataset
uspto-grants-2006_05
Patent number
US07053122B2

Reaction notes

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