2-Chloropyrimidine → Benzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate

HRID 1827119Notes

Reaction equation

HRID 1827119 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH2:4]1.Cl[C:20]1[N:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[N:21]1[CH:22]=[CH:23][CH:24]=[N:25][C:20]=1[NH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 219554994-Aminomethyl-1-N-Cbz-piperidine

Product 1

HCID 9923385Benzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate

Procedure

The title compound was prepared as described in EXAMPLE 13, except using benzyl 4-(aminomethyl)-1-piperidinecarboxylate (6.50 g, 26.19 mmol) and 2-chloropyrimidine (990 mg, 8.64 mmol) as starting materials without a solvent to give the title compound as a yellow oil.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-0b34ae9c11784acba231fe44a95fe1ba
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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