4-Chloro-2-methylthiopyrimidine → 4-Methylbenzyl 4-({[2-(methylsulfanyl)-4-pyrimidinyl]amino}methyl)-1-piperidinecarboxylate

HRID 1827122Notes

Reaction equation

HRID 1827122 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH2:4]1.Cl[C:21]1[CH:26]=[CH:25][N:24]=[C:23]([S:27][CH3:28])[N:22]=1>>[CH3:28][S:27][C:23]1[N:24]=[C:25]([NH:1][CH2:2][CH:3]2[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]3[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=3)=[O:10])[CH2:5][CH2:4]2)[CH:26]=[CH:21][N:22]=1

Participants

3

Reactant 2

HCID 971134-Chloro-2-methylthiopyrimidineHCID 161094174-Methylbenzyl 4-(aminomethyl)1-piperidinecarboxylate

Product 1

HCID 101347674-Methylbenzyl 4-({[2-(methylsulfanyl)-4-pyrimidinyl]amino}methyl)-1-piperidinecarboxylate

Procedure

The title compound was prepared as described in EXAMPLE 13, except using 4-methylbenzyl 4-(aminomethyl)-1-piperidinecarboxylate (600 mg, 2.29 mmol), and 4-chloro-2-methylthiopyrimidine (386 mg, 2.40 mmol) as starting materials and gave the title compound as a yellow oil.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-0f82f1b2a8e74627b75962cb823e8a4d
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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