2-Aminothiazole → HCID 10131619, compound

HRID 1827126Notes

Reaction equation

HRID 1827126 reaction equation
[CH:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH2:4]1)=O.[NH2:19][C:20]1[S:21][CH:22]=[CH:23][N:24]=1>>[S:21]1[CH:22]=[CH:23][N:24]=[C:20]1[NH:19][CH2:1][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 2776272Benzyl 4-formylpiperidine-1-carboxylate

Product 1

HCID 10131619HCID 10131619, compound

Procedure

The title compound was prepared as described in EXAMPLE 25, except using benzyl 4-formyl-1-piperidinecarboxylate (300 mg, 1.21 mmol) and 2-amino-1,3-thiazole (133 mg, 1.33 mmol) as starting materials to give the title compound as a yellow oil.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-7bc954d9f1e84af29efea9d2dc9b6631
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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